Chronic Gastritis & Gastroduodenitis
Ozone has proved to be effective in treating chronic gastritis and gastroduodenitis associated with Helicobacter pylori through its influence on the main pathogenetic mechanisms of these diseases: the bactericidal action against numerous bacteria and helicobacter; the anti-inflammatory effect through the oxidation of arachidonic acid that is a predecessor of prostaglandin E initiating the inflammatory process; the immunomodulating and anti-aggregating effects as well as the analgesic effect.
Recently, several variants have been developed and clinically tested for treatment of this pathology with ozone/oxygen gas mixtures including different combinations of available methods of ozone therapy. For example, combination of rectal ozone insufflations, minor ozonated autohaemotherapy, ozonated oil and water per os (S.V.Andosov, V.I.Almazov, 2000); combination of intravenous infusions of ozonated saline and ozone gas injections into the biologically active points.
The received clinical results have been verified through the endoscopic, histological, biochemical, immunological investigations. On the 2nd or 3rd day of treatment it comes to elimination of endotoxic symptoms, pain and dyspeptic syndrome; improvement of defense properties of mucoepithelial barrier that results in an increase in the height of surface epithelium and stimulation of the main function of mucocytes (S.D.Karataev, V.A.Maximov, 2000). It comes to a decrease in the deficit of secretory IgA produced by the lymphocytes and plasmatic cells of lymphoid tissue of gastric mucous membrane. One of the most important indicators for successful therapy is a long-term relapse-free period. In this pathology ozone therapy has proved to be an ideal monotherapy, but when used in combination with physical therapy it is possible to increase the efficiency of treatment (I.P.Shmakov, 2001).
The many-sided action of ozone therapy in the treatment of ulcerous disease mostly develops through its anti-inflammatory, anti-helicobacter, regenerating and stimulating effects. Owing to its interaction with the microflora, ozone produces a powerful bactericidal effect and decreases resistance of the remaining microorganisms to antibiotics. Active oxygen ensures elimination of tissue hypoxia and creates favorable conditions for regenerative processes improving the disturbed microcirculation at the pathological area through the spasmolytic action and normalization of the rheology of blood. This results in acceleration of ulcer epithelization, disappearance of mucosal infiltrate much faster than after the traditional therapy.
A decrease in the inflammation of gastric or duodenal mucous membrane is achieved both through the systemic action via the parenteral route of administration of ozone/oxygen gas mixture and local action of ozonated products. An increase in the immunity through ozone therapy considerably improves remote results of treatment and reduces a risk of disease recidivation. Ozone therapy can be used as a monotherapy or in combination with other therapeutic methods.
Recommended methods of ozone therapy:
· Ozonated water;
· Ozonized oil;
· Rectal ozone insufflations;
· Minor autohaemotherapy with ozone;
· Intravenous drop-by-drop infusions of ozonated saline solution;
· Acupuncture therapy with ozone.
One of the clinical investigations included 69 patients (10 with gastric ulcer and 59 with duodenal ulcer) in the period of aggravation, who received ozone therapy as a monotherapy. The results received in the treatment of 8 patients with gastric ulcerous disease were interpreted as a significant improvement: complete ulcer scarring and disappearance of all disease symptoms. In 2 cases clinical symptoms of disease were completely removed, but ulcer healing was not complete, and the result of treatment was evaluated as an improvement in the patient's condition.
The patients with duodenal ulcerous disease after the course of ozone therapy showed a significant improvement in 56% of cases, an improvement - in 39% of cases, a partial improvement with some symptoms remained and incomplete ulcer healing - in 5% of cases. Ozone therapy can be used both as a monotherapy and in addition to drug therapies. Its anti-bacterial effect is particularly important. It can substitute the use of antibiotics and metronidazol. Moreover, ulcer healing, elimination of mucosal infiltrate, eradication of Helicobacter Pylori are achieved through ozone therapy in considerably more cases than with traditional treatment (V.A. Maximov et al).