OZONE
THERAPY IN THE OBSTETRICS & GYNAECOLOGY
Obstetrics
and gynecology can be with certainty numbered among the fields of medicine
where the whole spectrum of therapeutic properties of ozone can be successfully
used. The list of indications for ozone therapy is as wide as the totality of
medical problems requiring an improvement of macro- and microcirculation,
correction of immunological status or lipid peroxidation processes. Owing to
the capacity of medical ozone to act on the basic links of pathogenesis, ozone
therapy has proved to be particularly effective in the following pathologies:
·
Spontaneous abortion
·
EPH-gestosis
·
Pregnancy anemia
·
Early toxicosis
·
Fetoplacental
insufficiency
·
Inflammatory diseases
of internal genital organs (adnexitis, endomyometritis)
·
Inflammatory diseases
of lower female genital organs (colpitis, endocervicitis, bacterial vaginosis)
·
Oncogynecological
pathology
·
Vulva dystrophy
Ozone
therapy is successfully used fro prophylaxis of:
·
Intrauterine fetus
infection
·
Fatness-associated
pregnancy complications
The
therapeutic effect of ozone is based on the well-known mechanisms of its
biological action:
1.
Owing to its high
oxidating power, highly concentrated ozone used at the local level produces a
bactericidal, fungicidal and viricidal effect versus the most important species
of gram-positive and gram-negative bacteria, viruses, pathogenic fungi and
protista;
2.
The systemic effect of
medium and low ozone concentrations produced by parenteral route of
administration in medical conditions associated with hypoxia situations is
based on the activation of the oxygen-dependent processes;
3.
The ozonides resulted
from the ozonolysis of unsaturated fatty acids modify cell membranes at the
structural-functional level, intensify the enzymatic systems and thereby
improve the energy metabolism.
4.
The immunomodulating
effect of ozone is based on its ability to activate the phagocytosis through
the formation of peroxides and stimulation of the production of cytokines by
lymphocytes and monocytes.
5.
Modification of blood corpuscle
membranes and fine-structure of vascular bed as well as a decrease in the
viscosity properties of blood lead to an improvement of the blood micro-flow
and respiratory metabolism at the tissue level.
Before
the practical use of ozone in clinics for women, the following fundamental
facts were experimentally established:
1.
During the pregnancy
ozone concentration in gas mixture bubbled into saline solution (method of
intravenous drop-by-drop infusions of ozonated saline solution) may range
within 400-800 mcg per liter. This result was obtained on the basis of
investigations into the influence of different ozone concentrations on the
parameters of lipid peroxidation and antioxidant defense system in blood
samples taken from the patients with different obstetric pathologies (series of
experiments in vitro).
2.
The safety of these
ozone concentrations relating to teratogenecity was confirmed by a series of
experiments in vivo on pregnant laboratory rats.
Further
fundamental investigations have fully confirmed the applicability of ozone
therapy in the treatment of gestational complications since it has been
reliably established that the use of ozone leads to correction of basic links
of the pathogenesis and the most important clinical appearances of disease:
·
Improvement of macro-
and microcirculation that results in the normalization of placenta hormonogenic
function;
·
Decrease in the
activity of lipid peroxidation processes and simultaneous stimulation of the
antioxidant defense system of human body;
·
Immunomodulating
action develops particularly through a decrease in blood level of circulating
immune complexes, IgM, group and Rh antibodies, increase in the phagocytic
activity of neutrophiles;
·
Decrease (if available)
in the hypercoagulation activity of blood;
·
Intensification of the
protein-synthesizing function of liver;
·
Ozone therapy exerts a
beneficial influence on the clinical course of threatened abortion, gestosis,
pregnancy anemia, fetoplacental insufficiency, reduces a risk of intrauterine
fetus infection and a risk of fatness-associated pregnancy complications,
improves a prognosis of these diseases;
·
Ozone therapy reduces
stationary treatment time, reduces the use of medicinal agents;
·
Ozone therapy significantly
reduces a risk of such complications as delivery weakness, postnatal and early
postnatal bleedings;
·
The use of ozone as a
component of treatment complex improves perinatal adaptation of newborn
children.
Inflammatory
diseases of pelvic organs i.e. internal genitals being considered one of the
most frequent pathologies of the woman's body require a new therapeutic
approach due to resistance of microorganisms to available antibiotics, high
allergization of human body, immunodeficiency and metabolic disturbances
associated with the basic pathology.
As
a result of the experiments conducted in vivo the pathogenetically proved and
at the same time safe ozone concentration is 1200 mcg/L bubbled into saline
solution.
The
clinical investigations allow making the following conclusions:
1.
Ozone therapy for
inflammatory diseases of pelvic organs is considered as a component of
antioxidant therapy as well as exerts a corrective influence on the cellular
and humoral immunity confirmed by an increase in immunoregulative index, a
decrease in the level of IgM and circulating immune complexes.
2.
The addition of
medical ozone to the multimodality therapy exerts a positive influence on the
clinical appearances of acute inflammatory diseases of pelvic organs providing
a detoxication, analgesic and sedative effect that allows considerably reducing
the use of appropriate traditional medicaments. This improves immediate
results, particularly reduces residuals of inflammation. A decrease in relapse
percentage after the use of ozone as a component of pathogenetic therapy speaks
in favor of optimization of remote results.
The
experimental-clinical investigations into the influence of ozone on the course
of inflammatory processes of lower female genital organs have shown that ozone
in gas phase at certain concentrations and methods of administration exerts a
beneficial influence on the factors of local genital immunity that allows
stopping the inflammation.
The
well-known antimicrobic properties of ozonized olive oil as found out can be
successfully used in the treatment of vulvar dystrophic diseases. Ozone therapy
produces not only an anti-inflammatory effect, but also improves tissue
trophism, allows rejecting the use of hormonal ointments and laser therapy.
The
practice has shown that the method of intravenous drop-by-drop infusions of
ozonated saline solution is the most suitable and applicable one for obstetric
clinic. Saline solution is the optimal carrying agent of ozone as it does not
undergo any chemical conversions during the ozonization. Ozonated saline
solution is produced by conveying an ozone-oxygen gas mixture through a
standard glass bottle with 400 ml of sterile 0,9% sodium chloride solution for
15-20 minutes (by using a 200 ml bottle the ozonization lasts for 10-15 minutes).
With consideration for instability of ozone in aqueous medium, the ozonated
saline solution should be used immediately after its production. It is
recommended to administer the ozonated saline solution in the form of drips
into the cubital vein at a flow rate of 8-10 ml per minute similar to flow
infusions that ensures a minimum loss of ozone. With consideration for
dose-related effects of ozone, it is necessary to strictly follow the given
mode of ozonization. The safety measures are usual for intravenous infusions.
The
method of intravenous drop-by-drop infusions of ozonated saline solution has
proved very well in the treatment of inflammatory diseases of pelvic organs as
well. Systemic ozone therapy can be also provided in the form of flow rectal
insufflations of an ozone/oxygen gas mixture.
In
case of inflammatory process in uterine or vaginal cavity it is possible to use
the antimicrobic effect of ozone in different variants of its local application
(as a carrying agent of ozone can be used distilled water, purified olive oil,
ozone therapy in gas phase is possible too).
Ozonized
distilled water is produced like the ozonated saline solution, but with
consideration that the half-life of ozone in distilled water is more (1,5-2
hrs); therefore the ozonized distilled water keeps its properties longer than
the ozonated saline solution.
Production
of ozonized olive oil requires more time due to lower solubility of ozone in
olive oil and depends on the volume of oil produced (ozone saturation of 100 ml
of oil lasts for 2 hrs). It is recommended to use the ready-made ozonized olive
oil O'THREE-Ozonide.
The
use of ozone in gas phase is possible by means of special attachments as
demonstrated below:
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