- ILLNESS WE TREAT

Illnesses we treat

Ozone (O³) treats more than 134 serious illnesses.                                       here are just some of them :

·       Acute and chronic pain.

·       Connective tissue diseases (e.g. Rheumatoid arthritis, Systemic Lupus Erythomatosus)

·       Diseases of the myosceletic and joint system including all types of arthritic cases (e.g. Arthrosis, Arthritis, Osteochondrosis of the backbone, Myositis, Reactive arthritis).

·       Posttraumatic conditions and consequences from any kind of trauma.

·       Postoperative complications (eradicating purulent infection, healing of wounds).

·       Nervous system diseases (neurosis, stress, phsychosomatic frustration, nerve inflammation).

·       Diabetes and its complications. (e.g. Diabetic foot, Impotency).

·       Inflammatory bowel diseases (Crohn’s disease, ulcerative colitis).

·       Encephalopathy of various etiologies.

·       Viral infections (Hepatitis, Herpes Zoster, Bell's Palsy etc.)

·       Diseases of the respiratory system (chronic pneumonia, chronic bronchitis, emphysema οf lungs, bronchial asthma).

·       Skin diseases (dermatitis, psoriasis, eczema, fungous diseases)

·       Urologic and Aphrodisiac infections.

·       Autoimmune diseases

·       Intoxications of various etiology.

·       Consequences of insult.

·       Rehabilitation of old age patients.

·       Impotency and Prostatitis

·       Allergies and allergic reactions.

·       Varicose veins, thrombophlebites

·       Cellulitis  & Gangrene

- OZONE: CELLULITE TREATMENT

Cellulite treatment

According to various sources, 80% to 95% of women are suffering from cellulite. Usually the areas where cellulite appears are buttocks and hips (the back and hands are more rare,as a rule, with obesity). The reasons for the appearance of this illness weren’t found, although the predisposing factors are indicated: hormonal disturbances in the organism of woman, vascular diseases, hypodynamia, etc.

The reasons of cellulites also can be:

·       Genetic predisposition;

·       Hormonal disturbances;

·       The low-mobility way of life;

·       Incorrect nourishment.

Correct and timely diagnostics is one of the guarantees of the successful treatment of cellulite. Primary cellulite  visual inspection by doctor with measuring the thickness of skin fold and the circle of thigh. All these methods are good, but still they are not very precise. The only precise method of diagnostics of cellulites is thermal scanning. One of the very first consequences to what leads cellulites is disturbance of blood microcirculation. The temperature of the struck section changes because of this. The "warm" and "cold" zones appear.

All this is mapped in the plates of thermograph, thus, is manifested the "thermal map of cellulites". The "pictures” will be different depending on the stages of cellulites. Within the standard it is evident that the uniform image designates identical temperature, absence of hem stasis and lymph, nodular thickenings.

Noncontact thermography is an absolutely safe method, which is adapted without any limitations. The treatment of cellulite must be directed, in the first place, toward the elimination of the reason of disease; in the second, to correction of the pathogenesis mechanisms of the development of disease and, thirdly, to liquidation of its manifestations and consequences. All these problems successfully are solved with the help of ozone. It is  more rational to begin to treat cellulite at early stages, when it presents as an aesthetical problem only. In this case, ozone can be used as a mono-therapy and several procedures of the subcutaneous introduction are enough in order to obtain a good cosmetic effect. The usual course of the therapy by ozone consists of the specific quantity of sessions (from 10 to 20) with the periodicity of 1-3 times in the week. Gas is introduced hypodermically with the help of the special micros-needle with the length of 4 or 13 mm. Microcirculation is improved, and therefore subcutaneous fat cellulose stimulates saturation of cells by oxygen and nutrients, and facilitates combustion of fat. Adding to the above, ozone not only activates fat metabolism, but also starts the mechanism of the natural processing of its own, reserves the energy from the fatty deposits.

The positive results of treatment are already observed after 3-5 sessions and are well noticeable both to the doctor and the patient, who begin to note an ease in the lower extremities and decrease of edema. In the following stage the form of "orange peel” is reduced or completely disappeared, volumes of hypodermic fatty layer and areas of the struck zones are decreased. The rise of local temperature testifies about the normalization of microcirculation and the restoration of metabolic processes. In our view the best result is achieved only by complex treatment; therefore we combine the hypodermic introduction of ozone with the subsequent treatment of problematic zones with Magic Slim machine.

- OZONE FOR GANGRENE

OZONE FOR GANGRENE

Gangrene is the most serious symptomatic feature or cardinal sign of arterial insufficiency, after intermittent claudication and rest pain. Gangrene is necrosis or death of tissue, and commonly affects the extremities of the hands and feet (Hoffman 1992). 

 When presented with gangrene, the clinician must determine the cause of the pathology, so as to address it and prevent further damage. Whilst ischaemia may be evaluated as being the cause, it should be determined whether it was from atherosclerosis, myocardial infarct, valvular heart disease or emboli. Also ascertain if they are a smoker, have diabetes mellitus, and history of vascular problems. Treating gangrene is beyond the scope of a podiatrist, so if gangrene is found, refer to a vascular surgeon. 

 The podiatrist may see gangrene as dry or moist (Hoffman 1992). Dry gangrene is most commonly due to ischaemia and is often a secondary complication of type 2 diabetes mellitus. It presents as cold, dry, shriveled and blackened tissue, often running deep into the fascia, but first appearing on the distal apices. 

 Wet or moist gangrene is the more serious condition, as it usually indicates a bacterial infection that may quickly spread and be fatal. Most commonly caused by an acute occlusion, such as tourniquet, restrictive bandage or trauma. It present like dry gangrene, but is softer to touch with an offensive odour, and the foot may be swollen, red and warm (Lorimer et al, 1997, Hoffman 1992). 

As mentioned previously, presence of gangrene must be taken seriously and appropriate referrals made immediately

GANGRENE CASE REPORT

Patient A

Case report: Treatment of Diabetic Ulcers and Gangrene with Complex therapy Surgery and Ozone Therapy.

Patient A female 58 years old has visited us in May 2007 for treatment with diagnosis of gangrene of the left foot and toes, diabetic angiopathy. The patient had been on standard medical treatment of antibiotics and wound sanitation with minimal or no effect.

Brief history: the patient suffers from diabetes mellitus type 2 for the last 10 years, and was on treatment of Glucophage 500mg tablets 3 times/day, for the last 10 years. On an angiogram performed at that time it was found that the patient had a full block in her vessels in the left leg foot and terminal segment of the leg.

Complaints: the patient mainly complained of pain in the left foot and no sensation in the left leg, lower knee region, weakness, patient’s daily life activities were limited as the patient had to use a wheelchair to move, due to this the patient also had depression, bad appetite and intoxication like general condition.

Physical examination: the patient feels severe pain on any contact near the gangrene site and from the gangrene wound on the left foot there is strong bad smell.

The patient’s gangrene started about 5 months before the first consultation at our institute, it was initially spread to the 2nd, 3rd, 4th, and 5th small toe leaving out the hallux or the big toe. Amputation surgery was performed to stop the spread of gangrene but the surgical wound was not able to heal properly and the gangrene spread from the phalanges to the metatarsal region. In consultation with surgeon Dr. Andreas Demitrou it was decided not to amputate above the tarsal region {because the patient is of a very small physical stature and is obese, if the amputation was performed till the knee joint the stub will be small after surgery and it will be difficult to place a prosthetic support on it. Meaning that the patient will have severe limitations of life activities}. Thus the treatment regime for the patient was planned in such way, so as to maximize the patient’s abilities and minimize tissue loss.

Treatment: -presurgical- The patient was started initially on high dosage I.V. ozone therapy once a day accompanied by direct superficial ozone application in the form of ozone bags at the site of the gangrene on the left foot and as prophylaxis for small ulcers that were present on the right leg.

The surgical operation was performed by senior surgeon Dr. Andreas Demitrou, and was a success, all gangrenous tissue and surrounding affected tissue zone was meticulously removed leaving healthy tissue, thereby saving maximum possible. This surgery was optimal keeping in mind the patient’s future and life and was done without any complications. Thereby providing the patient with an excellent chance of walking again with the help of prosthetic implants. Postsurgical-the patient was given I.V. ozone therapy.

Result: the patient received in all more than 40 sessions of high dosage I.V. ozone therapy pre and post surgical and an excellent surgical intervention by Dr. Andreas Demitrou. This combination proved to be beneficial for the patient as it gave the patient a chance to resume maximum of her physical and daily life activities with the help of a prosthetic implant.

·       For the next four and a half months (18 weeks), all wounds on the patient were healed.

·       She was recommended special orthopedic shoes.

·       The patient was also recommended to loose weight as she is of a small stature with a body weight of over 100 kgs and a height of 157 meters.

·       The patient has also been advised prophylactic ozone therapy every 6-8 months. Ozone therapy is given here to decrease cholesterol accumulation in her blood vessels thereby decreasing the chances of vascular blockages being formed.

·       Present day: the patient has resumed all life activities and walks small distance of about 200metres without any kind of support. 

Report prepared by Institute of Medical Rehabilitation:
Director: Dr. Nikolenko Yuri M.D. PhD 
Dr. Andreas Demitrou M.D. PhD (President, Cyprus Medical Association)
Dr. Mayank Gaur M.D.; Dr. Valentina Nikolenko M.D.; Dr. Nikoletta Nikolenko M.D.

Patient B

Case report: Treatment of Diabetic ulcer with Ozone Therapy.

Patient B male, 62 years old has visited us in July 2004 for treatment with diagnosis of diabetic ulcer on the right metatarsal region just under the hallux (big toe). The patient has been suffering from diabetes mellitus type 2 for the last 15 years and has been receiving insulin and Glucophage tablets for it during this time.

The patient had been undergoing standard medical treatment for gangrenes of antibiotic therapy plus wound sanitation for the last 7 months with no effect. During this time as result of the medical treatment was not satisfactory a decision for amputation was taken.

Complaints: The patient came to our institute about 5 years ago with primary complaints of pain in the right foot.

Physical examination: on examination the patient was found to have a big ulcer on the metatarsal region of the foot with gangrene formation in the initial stages.

Treatment: High dosage I.V. Ozone therapy – 20 sessions accompanied by ozone bag for superficial wound healing.

Result:

·       On the 60th day of treatment initiation the patient started walking and wears shoes and works in an industrial unit.·       On the 22nd day of treatment initiation – the ulcer healed and scar formation was observed.

·       For the last 5 years the patient has been coming for prophylactic ozone therapy every 8 months.

·       Residive has not occurred for all this time.

Report prepared by Institute of Medical Rehabilitation:
Director: Dr. Nikolenko Yuri M.D. PhD 
Dr. Mayank Gaur M.D.; Dr. Valentina Nikolenko M.D.; Dr. Nikoletta Nikolenko M.D.

Patient C

Case report: Treatment of Trophic Ulcer in a diabetic patient with ozone therapy and surgical sanitation of the wound.

Patient C male, 72years old, has visited us for treatment of post amputative trophic ulcer of the right leg big toe. The Trophic ulcer did not heal with conservative treatment for a time period of two years. The patient suffered from severe pain and could not stand on his legs due to which he had to use crutches to move around, thereby, limiting his daily life activities.

Anamnesis: the patient suffers from diabetes mellitus type 2 and was taking Glucophage 500mg tablets 3times/day with insulin. The patient suffered from gangrene of the big toe about 6 months ago and surgical amputation procedure was performed. But the gangrene wound did not heal completely.

Treatment: High dosage I.V. Ozone therapy accompanied by ozone bags for superficial wound healing- 25 sessions were done. Pain was completely relieved by the end of the therapy.

Result: after 45 days of treatment initiation the gangrene/ulcer site was healed and the only visible sign was the presence of crusting over it.

·       Present day, the patient has only a keloid scar at the site of the ulcer.·       After 65 days of treatment initiation the ulcer completely closed and the patient started to walk without support and could wear shoes normally without any discomfort.

Report prepared by Institute of Medical Rehabilitation:
Director: Dr. Nikolenko Yuri M.D. PhD 
Dr. Mayank Gaur M.D.; Dr. Valentina Nikolenko M.D.; Dr. Nikoletta Nikolenko M.D.

- OZONE: SPINAL OSTEOCHONDROSIS

Neurological Appearances of
Spinal Osteochondrosis

Spinal osteochondrosis is considered a chronic systemic disease of connective tissue which development requires genetic disposition and manifestation - exposure to exo- and endogenous   factors. Among the first ones there are numbered physical, chemical and infectious agents, and among the second ones - certain constitutional variants, spinal anomalies, peculiar function of motional system, associated diseases of spine and other organs (V.P.Veselovsky, 1991).

This multi-factor disease first affects intervertebral disc and then other sections of locomotor apparatus and nervous system (O.G.Kogan et al., 1983).

Among the neurological appearances of spinal osteochondrosis vertebrogenic pain syndrome is of greatest importance for adequate evaluation of efficiency of the treatment performed. This syndrome consists of 4 components: muscle pain, fascial-ligamentous pain, joint pain, discogenic pain.

According to the above-mentioned, the conservative treatment of patients with neurological appearances of spinal osteochondrosis should be complex, differential and based on the main pathogenetic mechanisms of disease. The therapeutic measures should be focused on both the vertebral area of affection and extravertebral appearances.

There are 5 main principles of therapy for vertebrogenic diseases of nervous system:

1.exclusion of adverse static-dynamic loads;

2.stimulation of muscle corset;

3.phase and complete exposure;

4.decrease in pain feelings;

5.careful character of therapeutic measures.

The latter 4 principles can be fully realized by methods of regional (local) ozone therapy specially developed for neurological appearances of cervical and lumbar osteochondrosis.

Recommended methods of regional (local) ozone therapy:

·   Minor autohaemotherapy with ozone;

·   Paravertebral ozone injections;

·   Subcutaneous ozone injections into the biologically active points;

·   Intramuscular ozone injections into the trigger points.

Ozone therapy was used within the complex treatment including non-steroid anti-inflammatory medicines, vitamins of B group, sedative preparations, therapeutic exercises.

The approximate schema of sanogenetic reactions developed in patients with neurological appearances of spinal osteochondrosis through regional ozone therapy includes:

1.Decrease in the irritation of sinuvertebral nerve ends due to the decreased action of: 

a) the discirculatory factor, a decrease in the edema of surrounding tissues;

b) the dislocation factor due to partial restoration of amortization properties of the affected disc, as a result, improvement of its metabolism and activation of trophic influences;

c) the aseptic-inflammatory factor induced by the synthesis of prostaglandins as inflammation mediators and activation of cellular immunity contributing to fast elimination of "foreign" components. As a result, it comes to a significant decrease in afferent flow from periphery to CNS.c) aseptic-inflammatory factor induced by the synthesis of prostaglandins as inflammation f cellular immunity contributing to fast elimination of "foreign" components. As a result, it comes to a significant decrease in afferent flow from periphery to CNS.

2.Actual antinociceptive action of ozone therapy connected with:

a) direct oxidation of algopeptides;

b) a decrease in underoxidated products in spasmodic muscles;

c) an increase in excitability threshold of pain receptor membranes (membrane-stabilizing effect).c) an increase in excitability threshold of pain receptor membranes (membrane-stabilizing effect).

3. Improvement in the function of spinal segmental apparatus manifested as:

a) acceleration of formation of a new motional stereotype;

b) activation of spinal mechanisms of pain control;

c) normalization of vegetative-trophic basis of motional act.c) normalization of vegetative-trophic basis of motional act.

The above-mentioned can be considered a substitution for the use of regional ozone therapy in the complex treatment of patients with neurological appearances of spinal osteochondrosis.

- OZONE: NEUROPATHIES

Compressive Ischemic Neuropathies

Tunnel compressive ischemic neuropathy is a pathology of nerve trunk caused by its local irritation, compression and ischemia in anatomically and biochemically adverse conditions of nerve location (V.S.Lobzin, A.F.Rahimdzanov, N.M.Zhulev, 1988). This definition alone makes it clear that compressive ischemic neuropathy (CIN) is a polyetiologic disease. Considering the leading role of nerve trunk ischemia in the pathogenesis of CIN, for improvement of blood circulation, oxygen supply and function of compressed nerves it is advisable to use ozone therapy.

Recommended methods of ozone therapy:

·   Intravenous drop-by-drop infusions of ozonated saline solution.

Positive clinical results were received in 95% of cases with ozone therapy as a significant decrease in complaints, normalization of provocative tests, improvement of sensitivity in the zone of innervation of affected nerve. Owing to the considerable decrease or disappearance of night paresthesia of hands after the course of ozone therapy, it comes to normalization of night sleep, improvement of general state, increase in workability. Ozone therapy in the form of ozonated saline drips didn't cause any deterioration of the patients' state, side effects or complications (Yu.P.Potehina, 1997).

The improvement came as a rule after 3-6 procedures. After all, at the end of one course of ozone therapy the inhibition of lipid peroxidation processes and activation of antioxidant activity took place according to the data of biochemiluminescence analysis of blood plasma and determination of lipid peroxidation products.

The achieved results of treatment kept on average for 7 months. So, it is recommended to provide the patients with compressive ischemic neuropathies prophylactic courses of ozone therapy including 5-12 ozonated saline drips every two days, two times per year, in spring and autumn.

Summarizing the investigated and well-known mechanisms of action of ozone, ozone therapy in the form of ozonated saline drips is involved into the pathogenesis of compressive ischemic neuropathies at several stages:

1.Parenteral ozone therapy facilitates an increase in the partial oxygen pressure of arterial blood through the oxygen saturation of both plasma and erythrocyte hemoglobin (R.Chiong et al., 1990), which can induce a decrease in both general and local tissue hypoxia, activation of gas metabolism in the zone of ischemia.

2.Ozone is able to stimulate glucose metabolism in the erythrocytes, formation of 2,3-diphosphoglycerate - substance contributing to the more complete oxygen release by oxyhemoglobin and shift of oxyhemoglobin dissociation curve to the right (O.Rokitansky, 1982). Thus, more oxygen is released to the tissues, particularly affected by ischemia.

3.Owing to the interaction with corpuscle membrane lipids, ozone increases the deformability of the erythrocytes and decreases their aggregation and thus improves fluidity of blood in micro flow bed.

4.The ozonated saline drips improve peripheral blood circulation through the elimination of arteriolar spasm, increasing pulse blood filling and improving venous blood outflow to the limbs. Ozone can facilitate a decrease in arteriolar spasm and opening of non-functional capillaries thus activating microcirculation in the ischemized tissues.

5.Ozone used in therapeutic doses moderately decreases blood coagulation by shifting the values of coagulogram to the bottom level of norm, particularly in cases of initial tendency to hypercoagulation. This can help to decrease or prevent intravascular coagulation of blood, particularly in case of venous stagnation and ischemia. By inducing moderate hypocoagulation in the form of increase of activated recalcification time and activated thromboplastin time, decrease of platelet aggregation and activation of fibrinolysis, ozone is able to prevent thrombosis at the areas of decelerated blood flow and facilitates the lysis of produced small thromboses thus improving the rheological properties of blood.

6.Thanks to the improved blood circulation, particularly in micro flow bed, ozone possibly decreases tissue edema and tissue tension in the canal.

Thus, ozone actively involved into the pathogenesis of compressive ischemic neuropathies stimulates the restoration of affected nerve primarily through the improvement of microcirculation and rheology of blood. Ozone therapy without eliminating the main causes of nerve trunk compression decreases hypoxia and activates oxygen metabolism in the ischemized tissues. Such a pathogenetic action of ozonated isotonic solution is very important for nervous tissue where only aerobic processes can take place.

Ozone used by parenteral route can directly or indirectly influence on some mechanisms of formation of compressive ischemic neuropathies and at the same time break "adverse circles" of pathogenesis as well as optimize oxygen homeostasis in the compressed nerve trunk.

- OZONE: SCLEROSIS

Disseminated Sclerosis

Disseminated sclerosis is numbered to the group of demyelinating diseases of nervous system and characterized by the young contingent of patients, peculiar epidemiology and pathomorphology, difficulty in diagnosis and treatment.

The essence of disease is not limited by the formation of sclerotic plaques. The pathological process also involves immune system, different sides of metabolism, structures of vegetative nervous system (V.A.Karlov, 1990: E.I.Gusev et al., 1997; B.T.Haidarov, 1998).

According to most of the investigators devoted to this problem, disseminated sclerosis is a virus-induced disease. The leading role belongs to measles virus. The genetical determination of this disease is proven.

The complicacy of polysystemic, multi-level disturbances developed in this disease allows to determine some sanogenetic targets for efficient use of ozone therapy:

1.immunocorrection with accent on the cellular link of immunity;

2."leveling" of genetically determined and secondary developed disturbances of intracellular neurons' metabolism;

3.stabilization of myelin as biological membrane;

4.normalization of biochemical parameters and gas composition of blood;

5.restoration of "trophic control" on the part of vegetative nervous system.

The clinical investigation included 67 patients with disseminated sclerosis and 15 volunteers. Age of the investigated patients ranged from 19 to 49 years. Among the patients there were 39 women and 28 men. Average duration of disease was 3,8 years.

All the investigated patients were divided into 4 groups: 2 main (test) and 2 control (placebo). The treatment of patients of the 1st main group (n=22) along with standard therapeutic complex (prednisolon 30-60 mg/24 hrs, vitamins B, C, E, phytin, curantyl, ATP, T-activin, nootropil) included intravenous infusions of ozonated saline solution with ozone concentration. The patients of the 2nd main group (n=23) along with the above-mentioned standard treatment received ozone therapy in the form of intravenous infusions of ozonated saline solution in combination with per os intake of ozonated suspension of enterosorbent "Ensoral" in distilled water. This schema of treatment was based on the evidence about the efficiency of enterosorbents for patients with disseminated sclerosis as well as on the assumption about possible mutual potentiation of detoxication and immunomodulating effects of ozone and enterosorbents used in combination. And the great area of sorbing surface of "Ensoral" with structure C - C - C - C was considered a prerequisite for a certain "depot" of ozone within the whole gastroenteric tract. The selected ozone concentration is usually used for enteral methods of ozone therapy.

The received results have shown that the second variant of multimodality therapy has proved to be the most effective in the treatment of patients with disseminated sclerosis. The use of the above-mentioned treatment schema facilitated a decrease in the resistance to the performed therapy though the decrease in non-responders; prevention of increased deficit of T-lymphocytes (particularly T-suppressors) connected with the use of glucocorticoide hormones (parallel to regression of B-lymphocytes); normalization of vegetative tone in the cardiovascular system; increase in the transmission rate of nervous impulses through peripheral nerves.

- OZONE: MIGRANE

Migraine


Migraines are generally caused by seratonins released by red cell plateletes. Certain chemicals causes their release. A study in Italy found that 25% of migraines are also caused by the bacteria, H pylori.


Application of ozone therapy was based on the notions of a significant role of lipid peroxidation in the pathogenesis of migraine attacks. A therapy was performed in form of intravenous infusions of the ozonized physiologic solutions with ozone, concentration 1200 micrograms/l; a therapy course included 8-9 procedures.

The investigation included 68 patients: most of them had migraine without aura (64%); migraine with aura was diagnosed in 36% of cases. In the structure of aura visual disturbances and paresthesia were dominant. One patient had ophtalmoplegic migraine.

Average age of patients was 26,3 years. The women predominated over the men (71%). The frequency of migraine attack ranged from 2-3 per week to 5-6 per year. Most of the cases showed one-sided character of headache (73% of the investigated patients). In 32% of the patients paroxysms were associated with tension headache in the interictal period.

Ozone therapy was included into the complex treatment of 50 patients of the main (experimental) group.

Recommended methods of ozone therapy:

·   Intravenous drop-by-drop infusions of ozonated saline solution.

Along with neurological status, the results of treatment were evaluated on the basis of thorough examination of patients including the investigation into the cerebral neurodynamics, haemodynamics, vegetative regulation of heart rhythm, intensity of headache, anxiety, lipid peroxidation processes, antioxidant activity of blood plasma.

The results of dynamic observation have shown that the use of ozonated saline drips as a component of complex treatment increases its efficiency by 29%. The number of discharged patients with good therapeutic effect in main group (87%) was reliably higher than in control group (61%, p<0,05). The absence of non-responders among the patients received ozone therapy allows considering the latter as a reliable method of preventing resistance to the provided therapy in this contingent of patients.

Ozonated saline drips used in the interictal period ensured in 58% of the patients no migraine paroxysms within 4 to 8 months (in average 6,2 months) after their discharge from hospital. In other 19% of the patients the duration of attackless interval was limited to 3 months. However, after repeated migraine attacks, the frequency of attacks and intensity of headache were considerably less (on average 4,3+ 0,31 points according to the visual analog scale) than before the treatment.

The experience in the use of ozonated saline drips during the migraine paroxysm points out a clear correlation between the time from the beginning of headache to the point when ozone therapy was performed and its efficiency. As sooner the procedure was performed as less intensive was headache in further.

Basing on the received results it is obvious that the use of ozonated saline drips both as a component of complex treatment and as a monotherapy allows achieving a stable clinical effect in a relatively short time. The performance of repeated courses of ozone therapy with frequency 2-3 times per year allows to improve considerably the life quality of patients with migraine, significantly reduce the time of their disability.

The use of the above-mentioned methods of ozone therapy is more effective in the interictal period, but the method of ozonated saline drips can be included into the list of basic measures used for stopping migraine attack.

The efficiency of ozone therapy in the given contingent of patients was connected with the influence of the secondary products of ozone on the key pathogenetic mechanisms. The improvement of conditions for neuron's membrane function, normalization of rheological properties of blood through ozone therapy can be successfully added to immediate analgesic effect of ozonated saline drips through the interference of basic mediators of noci- and antinociceptive brain systems into the metabolism.